"Role of intracellular pathways exploited by viruses in tumor cell secretion of extracellular vesicles and their immune functions (2022-14-THERY_MARTIN)" project details

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General information

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2022-14-THERY_MARTIN

Extracellular vesicles; Tumor microenvironment; Immune responses; Virus; Immunotherapy

Role of intracellular pathways exploited by viruses in tumor cell secretion of extracellular vesicles and their immune functions

Director(s) and team

Clotilde Théry & Lorena Martin-Jaular

Extracellular vesicles, immune responses and cancer

Abstract

Cells release membrane-enclosed extracellular vesicles (EVs), which act as intercellular messengers, by transferring surface or internal signals into surrounding cells. The host laboratory aims at unraveling the diversity of EVs, with a goal to identify EVs able to induce anti-tumor immune responses. It has identified two proteins whose expression in virus-infected cells may change the downstream immune functions of their EVs. This project will explore this hypothesis in human cancer. Expression of the identified targets will be manipulated in breast cancer cell lines, and the consequences on EV release, tumor growth and immune responses will be evaluated. A long-term goal is to identify EVs with potential as anti-tumor immunotherapies in breast cancer.

Requirements to apply for the PhD thesis project

Applicants should have a strong desire to explore cell biological phenomena, and should show solid capacity for independent and creative thinking. Background in cell biology, and/or immunology is strongly recommended. Background in extracellular vesicles and bioinformatics is a plus but not compulsory. The project highly relies on biochemistry and flow cytometry techniques, for which the applicant should have either experience or a strong motivation to learn.